BID is a potential link between DNA damage and inflammatory responses in tumorigenesis
نویسندگان
چکیده
منابع مشابه
DNA damage and tumorigenesis.
Asacomplexpathologicprocess,tumorigenesishas involved various regulating mechanisms at molecular and cellular levels, particularly tightly related to DNA damage. In previous issues of JMCB, we have published several papers highlighting the relationship between tumorigenesis and DNA damage. As a guest editor, Dr Shen has organized a special issue on genomic instability and cancer (Shen, 2011). I...
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15 صفحه اولFunctional link between DNA damage responses and transcriptional regulation by ATM in response to a histone deacetylase inhibitor TSA.
PURPOSE Mutations in the ATM (ataxia-telangiectasia mutated) gene, which encodes a 370 kd protein with a kinase catalytic domain, predisposes people to cancers, and these mutations are also linked to ataxia-telangiectasia (A-T). The histone acetylaion/deacetylation- dependent chromatin remodeling can activate the ATM kinase-mediated DNA damage signal pathway (in an accompanying work, Lee, 2007)...
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ژورنال
عنوان ژورنال: OA Medical Hypothesis
سال: 2013
ISSN: 2053-0781
DOI: 10.13172/2053-0781-1-2-1025